Drug interactions
Elagolix + Mifepristone
Severity: Moderate
Elagolix and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise elagolix concentrations through CYP3A4 inhibition, while elagolix is a weak to moderate CYP3A4 inducer that may lower mifepristone exposure. Higher elagolix exposure increases bone mineral density loss and liver enzyme risk.
What this interaction means in plain words
Elagolix and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of elagolix, while elagolix induces CYP3A4 and may reduce mifepristone levels.
What to do
Limit elagolix to 150 mg once daily and restrict duration as in labeling for strong CYP3A inhibitors. Monitor mifepristone response and adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Mifepristone?
MediHelp rates the interaction as moderate. Elagolix and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may raise elagolix concentrations through CYP3A4 inhibition, while elagolix is a weak to moderate CYP3A4 inducer that may lower mifepristone exposure. Higher elagolix exposure increases bone mineral density loss and liver enzyme risk.
How serious is the interaction between Elagolix and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit elagolix to 150 mg once daily and restrict duration as in labeling for strong CYP3A inhibitors. Monitor mifepristone response and adjust the dose as needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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