Drug interactions
Elagolix + Nadolol
Severity: Minor
Elagolix and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix inhibits P-glycoprotein and may modestly increase exposure to P-gp substrates such as nadolol. Enhanced beta blockade, including bradycardia or hypotension, is possible but likely small.
What this interaction means in plain words
Elagolix and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Nadolol belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux increases nadolol absorption and reduces its clearance.
What to do
Monitor heart rate and blood pressure after starting elagolix. Reduce the nadolol dose if symptomatic bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Nadolol?
MediHelp rates the interaction as minor. Elagolix and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix inhibits P-glycoprotein and may modestly increase exposure to P-gp substrates such as nadolol. Enhanced beta blockade, including bradycardia or hypotension, is possible but likely small.
How serious is the interaction between Elagolix and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting elagolix. Reduce the nadolol dose if symptomatic bradycardia occurs.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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