Drug interactions
Elagolix + Nicardipine
Severity: Moderate
Elagolix and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower nicardipine concentrations, reducing blood pressure control. It also inhibits P-glycoprotein, which could oppose this effect in part.
What this interaction means in plain words
Elagolix and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Nicardipine belongs to Cardiovascular.
Why it happens
Elagolix induces CYP3A4 and inhibits P-gp, producing unpredictable net changes in nicardipine exposure.
What to do
Monitor blood pressure and titrate nicardipine to response when elagolix is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Nicardipine?
MediHelp rates the interaction as moderate. Elagolix and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower nicardipine concentrations, reducing blood pressure control. It also inhibits P-glycoprotein, which could oppose this effect in part.
How serious is the interaction between Elagolix and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate nicardipine to response when elagolix is started or stopped.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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