Drug interactions
Elagolix + Nimodipine
Severity: Moderate
Elagolix and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A inducer and may lower nimodipine exposure. Reduced plasma concentrations could weaken the cerebrovascular protective effect of nimodipine, for example after subarachnoid hemorrhage.
What this interaction means in plain words
Elagolix and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Nimodipine belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by elagolix increases the first-pass and hepatic metabolism of nimodipine.
What to do
Monitor clinical response and blood pressure when elagolix is started or stopped. Consider a nimodipine dose adjustment if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Nimodipine?
MediHelp rates the interaction as moderate. Elagolix and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A inducer and may lower nimodipine exposure. Reduced plasma concentrations could weaken the cerebrovascular protective effect of nimodipine, for example after subarachnoid hemorrhage.
How serious is the interaction between Elagolix and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and blood pressure when elagolix is started or stopped. Consider a nimodipine dose adjustment if efficacy appears reduced.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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