Drug interactions
Elagolix + Paclitaxel
Severity: Minor
Elagolix and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and a P-gp inhibitor, so effects on paclitaxel exposure may go in either direction. The clinical significance is uncertain.
What this interaction means in plain words
Elagolix and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Paclitaxel belongs to Oncology.
Why it happens
Opposing effects of CYP3A4 induction and P-gp inhibition by elagolix on paclitaxel disposition.
What to do
No routine adjustment is needed. Monitor for changes in paclitaxel efficacy and toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Paclitaxel?
MediHelp rates the interaction as minor. Elagolix and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and a P-gp inhibitor, so effects on paclitaxel exposure may go in either direction. The clinical significance is uncertain.
How serious is the interaction between Elagolix and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for changes in paclitaxel efficacy and toxicity.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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