Drug interactions
Elagolix + Rifampicin
Severity: Major
Elagolix and Rifampicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin, a strong CYP3A inducer, can lower elagolix exposure and reduce its efficacy. Rifampicin may also be an inhibitor of OATP1B1 and raise elagolix levels after a single dose, so effects may vary with time.
What this interaction means in plain words
Elagolix and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Rifampicin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A metabolism by rifampicin, with additional effects on OATP1B1 transport.
What to do
Avoid concomitant use where possible and consider alternative antituberculous or hormonal therapy. If used together, limit elagolix treatment duration per the label.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Elagolix with Rifampicin?
MediHelp rates the interaction as major. Elagolix and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin, a strong CYP3A inducer, can lower elagolix exposure and reduce its efficacy. Rifampicin may also be an inhibitor of OATP1B1 and raise elagolix levels after a single dose, so effects may vary with time.
How serious is the interaction between Elagolix and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and consider alternative antituberculous or hormonal therapy. If used together, limit elagolix treatment duration per the label.
What other medicines interact with Elagolix?
MediHelp also lists interactions of Elagolix with, for example, Cyclosporin, Gemfibrozil, Desogestrel-ethinyl estradiol. The full list is on the Elagolix page.
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