Drug interactions
Elagolix + Roflumilast
Severity: Minor
Elagolix and Roflumilast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may reduce roflumilast exposure. The clinical effect is likely modest but could lessen COPD exacerbation prevention.
What this interaction means in plain words
Elagolix and Roflumilast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Roflumilast belongs to Respiratory.
Why it happens
Elagolix induces CYP3A4, increasing the metabolic clearance of roflumilast.
What to do
Monitor respiratory symptoms and exacerbation frequency during coadministration. No empiric roflumilast dose change is recommended.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Roflumilast
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Roflumilast?
MediHelp rates the interaction as minor. Elagolix and Roflumilast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and may reduce roflumilast exposure. The clinical effect is likely modest but could lessen COPD exacerbation prevention.
How serious is the interaction between Elagolix and Roflumilast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and exacerbation frequency during coadministration. No empiric roflumilast dose change is recommended.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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