Drug interactions
Elagolix + Saxagliptin-metformin
Severity: Minor
Elagolix and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and a P-gp inhibitor, so saxagliptin exposure could change in either direction. Effects are not expected to be large given saxagliptin's wide margin.
What this interaction means in plain words
Elagolix and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Elagolix induces CYP3A4 and inhibits P-glycoprotein, with opposing effects on saxagliptin exposure.
What to do
No empirical dose adjustment is needed. Monitor glycemic control during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Elagolix and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer and a P-gp inhibitor, so saxagliptin exposure could change in either direction. Effects are not expected to be large given saxagliptin's wide margin.
How serious is the interaction between Elagolix and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Monitor glycemic control during therapy.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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