Drug interactions
Elagolix + Secobarbital
Severity: Moderate
Elagolix and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower elagolix concentrations, potentially reducing its efficacy for endometriosis pain or fibroid bleeding. Elagolix is itself a weak-to-moderate CYP3A inducer, but the barbiturate effect is expected to dominate.
What this interaction means in plain words
Elagolix and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 and possibly P-glycoprotein or OATP-related pathways increases elagolix clearance.
What to do
Monitor symptom control and consider an alternative sedative. Avoid long-term use of strong inducers with elagolix.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Secobarbital?
MediHelp rates the interaction as moderate. Elagolix and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower elagolix concentrations, potentially reducing its efficacy for endometriosis pain or fibroid bleeding. Elagolix is itself a weak-to-moderate CYP3A inducer, but the barbiturate effect is expected to dominate.
How serious is the interaction between Elagolix and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider an alternative sedative. Avoid long-term use of strong inducers with elagolix.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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