Drug interactions
Elagolix + Simvastatin
Severity: Moderate
Elagolix and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower simvastatin exposure, while its P-gp inhibition may raise concentrations of some substrates. The net effect on simvastatin is likely reduced lipid-lowering, though elagolix can also increase concentrations of OATP1B1 substrates.
What this interaction means in plain words
Elagolix and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Simvastatin belongs to Cardiovascular.
Why it happens
Elagolix induces CYP3A4 and inhibits P-gp and OATP1B1, producing opposing effects on simvastatin exposure.
What to do
Monitor lipid response and muscle symptoms, and adjust the simvastatin dose as needed. Consider an alternative statin if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Simvastatin?
MediHelp rates the interaction as moderate. Elagolix and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower simvastatin exposure, while its P-gp inhibition may raise concentrations of some substrates. The net effect on simvastatin is likely reduced lipid-lowering, though elagolix can also increase concentrations of OATP1B1 substrates.
How serious is the interaction between Elagolix and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and muscle symptoms, and adjust the simvastatin dose as needed. Consider an alternative statin if the response is inadequate.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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