Drug interactions
Elagolix + Ticagrelor
Severity: Moderate
Elagolix and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer, which may lower ticagrelor exposure and reduce antiplatelet effect. It also inhibits P-glycoprotein, which could push ticagrelor levels in the opposite direction, so the net result is uncertain.
What this interaction means in plain words
Elagolix and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Ticagrelor belongs to Cardiovascular.
Why it happens
Mixed effect of CYP3A4 induction (lower ticagrelor exposure) and P-gp inhibition (higher exposure) by elagolix.
What to do
Monitor for reduced efficacy or increased bleeding and dyspnea. Consider an alternative if the clinical indication demands reliable platelet inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ticagrelor?
MediHelp rates the interaction as moderate. Elagolix and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer, which may lower ticagrelor exposure and reduce antiplatelet effect. It also inhibits P-glycoprotein, which could push ticagrelor levels in the opposite direction, so the net result is uncertain.
How serious is the interaction between Elagolix and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy or increased bleeding and dyspnea. Consider an alternative if the clinical indication demands reliable platelet inhibition.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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