Drug interactions
Elagolix + Tinidazole
Severity: Minor
Elagolix and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer, but tinidazole is eliminated by both renal excretion and hepatic metabolism, with CYP3A4 playing a partial role. Reduced tinidazole exposure is possible but is unlikely to be clinically important for a short antimicrobial course.
What this interaction means in plain words
Elagolix and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Tinidazole belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4 by elagolix may modestly increase tinidazole metabolism.
What to do
No empirical dose change is needed; assess clinical response to tinidazole and consider extending monitoring if treatment fails.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Tinidazole?
MediHelp rates the interaction as minor. Elagolix and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer, but tinidazole is eliminated by both renal excretion and hepatic metabolism, with CYP3A4 playing a partial role. Reduced tinidazole exposure is possible but is unlikely to be clinically important for a short antimicrobial course.
How serious is the interaction between Elagolix and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; assess clinical response to tinidazole and consider extending monitoring if treatment fails.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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