Drug interactions
Elagolix + Verapamil
Severity: Moderate
Elagolix and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower verapamil levels, reducing blood pressure or rate control. Verapamil may raise elagolix levels through P-gp inhibition.
What this interaction means in plain words
Elagolix and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Verapamil belongs to Cardiovascular.
Why it happens
Elagolix induces CYP3A4, while verapamil inhibits P-glycoprotein and CYP3A4, altering elagolix exposure.
What to do
Monitor heart rate and blood pressure and titrate verapamil if its effect diminishes. Limit elagolix duration or dose per labeling when taken with inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Verapamil?
MediHelp rates the interaction as moderate. Elagolix and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower verapamil levels, reducing blood pressure or rate control. Verapamil may raise elagolix levels through P-gp inhibition.
How serious is the interaction between Elagolix and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and titrate verapamil if its effect diminishes. Limit elagolix duration or dose per labeling when taken with inhibitors.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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