Drug interactions
Elagolix + Vinblastine
Severity: Moderate
Elagolix and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A inducer and also inhibits P-gp, so it may have opposing effects on vinblastine exposure. The net effect is unpredictable and could lead to reduced efficacy or increased toxicity.
What this interaction means in plain words
Elagolix and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Vinblastine belongs to Oncology.
Why it happens
Elagolix induces CYP3A4 and inhibits P-gp, with variable net effect on vinblastine exposure.
What to do
Monitor treatment response and for vinblastine toxicity such as cytopenias and neuropathy, adjusting the dose as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Vinblastine?
MediHelp rates the interaction as moderate. Elagolix and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak to moderate CYP3A inducer and also inhibits P-gp, so it may have opposing effects on vinblastine exposure. The net effect is unpredictable and could lead to reduced efficacy or increased toxicity.
How serious is the interaction between Elagolix and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and for vinblastine toxicity such as cytopenias and neuropathy, adjusting the dose as clinically indicated.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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