Drug interactions
Eletriptan + Fluconazole
Severity: Moderate
Eletriptan and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is extensively metabolized by CYP3A4, and fluconazole increases its exposure moderately. Higher levels may increase vasoconstrictive and other adverse effects such as hypertension and chest discomfort.
What this interaction means in plain words
Eletriptan and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of eletriptan.
What to do
Limit the eletriptan dose to the lower labeled dose and avoid repeat dosing within 24 hours. Monitor blood pressure and cardiovascular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Fluconazole?
MediHelp rates the interaction as moderate. Eletriptan and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eletriptan is extensively metabolized by CYP3A4, and fluconazole increases its exposure moderately. Higher levels may increase vasoconstrictive and other adverse effects such as hypertension and chest discomfort.
How serious is the interaction between Eletriptan and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the eletriptan dose to the lower labeled dose and avoid repeat dosing within 24 hours. Monitor blood pressure and cardiovascular symptoms.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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