Drug interactions
Eletriptan + Fluvoxamine
Severity: Moderate
Eletriptan and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic transmission, so combined use carries a risk of serotonin syndrome, although the reported incidence with triptans and SSRIs is low. Fluvoxamine is a weak CYP3A4 inhibitor and may slightly raise eletriptan exposure.
What this interaction means in plain words
Eletriptan and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from 5-HT1B/1D agonism plus serotonin reuptake inhibition, with weak CYP3A4 inhibition.
What to do
Counsel the patient on symptoms of serotonin syndrome such as agitation, tremor, sweating and diarrhea, and monitor especially at initiation or dose increases. Stop the triptan if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Fluvoxamine?
MediHelp rates the interaction as moderate. Eletriptan and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic transmission, so combined use carries a risk of serotonin syndrome, although the reported incidence with triptans and SSRIs is low. Fluvoxamine is a weak CYP3A4 inhibitor and may slightly raise eletriptan exposure.
How serious is the interaction between Eletriptan and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin syndrome such as agitation, tremor, sweating and diarrhea, and monitor especially at initiation or dose increases. Stop the triptan if symptoms appear.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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