Drug interactions
Eletriptan + Granisetron
Severity: Moderate
Eletriptan and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drug classes act on the serotonin system, and serotonin syndrome has been described with 5-HT3 antagonists combined with triptans. The risk appears low in practice. Triptans are taken intermittently, which limits exposure.
What this interaction means in plain words
Eletriptan and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Theoretical additive serotonergic activity (5-HT1B/1D agonism with 5-HT3 antagonism); the mechanism is not firmly established.
What to do
The combination can be used with awareness; counsel the patient to report agitation, tremor, sweating or fever. Stop both drugs and treat supportively if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Granisetron?
MediHelp rates the interaction as moderate. Eletriptan and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drug classes act on the serotonin system, and serotonin syndrome has been described with 5-HT3 antagonists combined with triptans. The risk appears low in practice. Triptans are taken intermittently, which limits exposure.
How serious is the interaction between Eletriptan and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used with awareness; counsel the patient to report agitation, tremor, sweating or fever. Stop both drugs and treat supportively if serotonin syndrome develops.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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