Drug interactions
Eletriptan + Iloperidone
Severity: Moderate
Eletriptan and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak CYP3A4 inhibitor and may slightly raise eletriptan levels. Serotonergic and dopaminergic overlap could rarely contribute to serotonin syndrome or neuroleptic malignant syndrome.
What this interaction means in plain words
Eletriptan and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition plus possible additive serotonergic and dopaminergic pharmacodynamic effects.
What to do
Monitor for signs of serotonin toxicity and for increased triptan adverse effects such as hypertension. Reduce use frequency or choose another triptan if problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Eletriptan with Iloperidone?
MediHelp rates the interaction as moderate. Eletriptan and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a weak CYP3A4 inhibitor and may slightly raise eletriptan levels. Serotonergic and dopaminergic overlap could rarely contribute to serotonin syndrome or neuroleptic malignant syndrome.
How serious is the interaction between Eletriptan and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity and for increased triptan adverse effects such as hypertension. Reduce use frequency or choose another triptan if problems occur.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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