Drug interactions
Eletriptan + Lasmiditan
Severity: Moderate
Eletriptan and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and in vivo, and eletriptan is a P-gp substrate. Exposure to eletriptan may increase. Also, both drugs are used for acute migraine, and lasmiditan has no vasoconstrictive effects, so using them together has little purpose.
What this interaction means in plain words
Eletriptan and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by lasmiditan may raise eletriptan absorption.
What to do
Avoid using both for the same migraine attack. Monitor for increased triptan adverse effects such as blood pressure elevation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Eletriptan with Lasmiditan?
MediHelp rates the interaction as moderate. Eletriptan and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and in vivo, and eletriptan is a P-gp substrate. Exposure to eletriptan may increase. Also, both drugs are used for acute migraine, and lasmiditan has no vasoconstrictive effects, so using them together has little purpose.
How serious is the interaction between Eletriptan and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both for the same migraine attack. Monitor for increased triptan adverse effects such as blood pressure elevation.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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