Drug interactions
Eletriptan + Lonafarnib
Severity: Major
Eletriptan and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-gp inhibitor but also a strong CYP3A4 inhibitor, which can raise eletriptan exposure substantially. Higher levels increase the risk of triptan adverse effects such as vasoconstriction.
What this interaction means in plain words
Eletriptan and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eletriptan belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib strongly inhibits CYP3A4 and weakly inhibits P-gp, reducing eletriptan clearance.
What to do
Avoid eletriptan with lonafarnib and use a triptan not dependent on CYP3A4, such as sumatriptan or rizatriptan, if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Eletriptan with Lonafarnib?
MediHelp rates the interaction as major. Eletriptan and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a weak P-gp inhibitor but also a strong CYP3A4 inhibitor, which can raise eletriptan exposure substantially. Higher levels increase the risk of triptan adverse effects such as vasoconstriction.
How serious is the interaction between Eletriptan and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan with lonafarnib and use a triptan not dependent on CYP3A4, such as sumatriptan or rizatriptan, if needed.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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