Drug interactions
Eletriptan + Lurasidone
Severity: Moderate
Eletriptan and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is a CYP3A4 substrate and lurasidone has weak serotonergic activity, so serotonin syndrome is theoretically possible but uncommon. Lurasidone is not a CYP3A4 inhibitor, so eletriptan levels are not expected to change.
What this interaction means in plain words
Eletriptan and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; lurasidone has 5-HT1A partial agonism and 5-HT2A antagonism.
What to do
No routine dose change is needed. Advise the patient to report agitation, tremor, fever or sweating, and monitor for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Lurasidone?
MediHelp rates the interaction as moderate. Eletriptan and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eletriptan is a CYP3A4 substrate and lurasidone has weak serotonergic activity, so serotonin syndrome is theoretically possible but uncommon. Lurasidone is not a CYP3A4 inhibitor, so eletriptan levels are not expected to change.
How serious is the interaction between Eletriptan and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Advise the patient to report agitation, tremor, fever or sweating, and monitor for signs of serotonin toxicity.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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