Drug interactions
Eletriptan + Pentazocine
Severity: Minor
Eletriptan and Pentazocine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been theoretically linked to serotonergic effects, and combined use could rarely contribute to serotonin syndrome. Clinical evidence for this pair is limited.
What this interaction means in plain words
Eletriptan and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eletriptan belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic activity; the mechanism for pentazocine is not firmly established.
What to do
Counsel the patient on symptoms of serotonin syndrome such as agitation, tremor, sweating and fever, and stop both drugs if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Pentazocine?
MediHelp rates the interaction as minor. Eletriptan and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been theoretically linked to serotonergic effects, and combined use could rarely contribute to serotonin syndrome. Clinical evidence for this pair is limited.
How serious is the interaction between Eletriptan and Pentazocine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin syndrome such as agitation, tremor, sweating and fever, and stop both drugs if they occur.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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