Drug interactions
Eliglustat + Linagliptin
Severity: Minor
Eliglustat and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and could modestly raise linagliptin concentrations, since linagliptin is a P-gp substrate. Linagliptin has a wide therapeutic margin, so a clinically important effect is unlikely.
What this interaction means in plain words
Eliglustat and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Linagliptin belongs to Endocrine.
Why it happens
P-glycoprotein inhibition by eliglustat reduces efflux of linagliptin.
What to do
No dose change is usually needed; monitor for hypoglycemia if other glucose-lowering drugs are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Linagliptin?
MediHelp rates the interaction as minor. Eliglustat and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and could modestly raise linagliptin concentrations, since linagliptin is a P-gp substrate. Linagliptin has a wide therapeutic margin, so a clinically important effect is unlikely.
How serious is the interaction between Eliglustat and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for hypoglycemia if other glucose-lowering drugs are also used.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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