Drug interactions
Eliglustat + Loratadine
Severity: Minor
Eliglustat and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and loratadine is a P-gp substrate, so loratadine levels may increase. Given loratadine's wide therapeutic margin, the clinical effect is expected to be small.
What this interaction means in plain words
Eliglustat and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Loratadine belongs to Respiratory.
Why it happens
Inhibition of P-glycoprotein efflux by eliglustat raises loratadine absorption.
What to do
No routine adjustment is required; monitor for drowsiness or headache. Reduce the loratadine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Loratadine?
MediHelp rates the interaction as minor. Eliglustat and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and loratadine is a P-gp substrate, so loratadine levels may increase. Given loratadine's wide therapeutic margin, the clinical effect is expected to be small.
How serious is the interaction between Eliglustat and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for drowsiness or headache. Reduce the loratadine dose if adverse effects occur.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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