Drug interactions
Eliglustat + Methamphetamine
Severity: Moderate
Eliglustat and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is a CYP2D6 inhibitor and methamphetamine is partly metabolized by CYP2D6, so methamphetamine levels may rise. This may increase stimulant and cardiovascular effects.
What this interaction means in plain words
Eliglustat and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Methamphetamine belongs to Central Nervous System.
Why it happens
Eliglustat inhibition of CYP2D6-mediated methamphetamine metabolism.
What to do
Monitor blood pressure, heart rate and stimulant adverse effects. Reduce the methamphetamine dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Methamphetamine?
MediHelp rates the interaction as moderate. Eliglustat and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat is a CYP2D6 inhibitor and methamphetamine is partly metabolized by CYP2D6, so methamphetamine levels may rise. This may increase stimulant and cardiovascular effects.
How serious is the interaction between Eliglustat and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and stimulant adverse effects. Reduce the methamphetamine dose if these occur.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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