Drug interactions
Eliglustat + Mirtazapine
Severity: Moderate
Eliglustat and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong the PR, QRS and QT intervals at high concentrations, and mirtazapine may add to QT effects. Eliglustat also inhibits CYP2D6 and is a CYP3A substrate, which may slightly increase mirtazapine exposure.
What this interaction means in plain words
Eliglustat and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with possible CYP2D6 inhibition raising mirtazapine levels.
What to do
Obtain a baseline ECG and monitor during combined therapy, especially with other QT risk factors. Watch for mirtazapine adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Mirtazapine?
MediHelp rates the interaction as moderate. Eliglustat and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong the PR, QRS and QT intervals at high concentrations, and mirtazapine may add to QT effects. Eliglustat also inhibits CYP2D6 and is a CYP3A substrate, which may slightly increase mirtazapine exposure.
How serious is the interaction between Eliglustat and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor during combined therapy, especially with other QT risk factors. Watch for mirtazapine adverse effects.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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