Drug interactions
Eliglustat + Risperidone
Severity: Moderate
Eliglustat and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6 and P-glycoprotein, both of which are involved in risperidone disposition, so risperidone and active 9-hydroxyrisperidone exposure may change and adverse effects may increase. Both drugs can also prolong the QT interval, adding to arrhythmia risk.
What this interaction means in plain words
Eliglustat and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 and P-gp by eliglustat, together with additive QT prolongation.
What to do
Monitor the ECG and for risperidone adverse effects such as extrapyramidal symptoms, and reduce the risperidone dose if they appear. Correct electrolyte abnormalities and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Risperidone?
MediHelp rates the interaction as moderate. Eliglustat and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits CYP2D6 and P-glycoprotein, both of which are involved in risperidone disposition, so risperidone and active 9-hydroxyrisperidone exposure may change and adverse effects may increase. Both drugs can also prolong the QT interval, adding to arrhythmia risk.
How serious is the interaction between Eliglustat and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and for risperidone adverse effects such as extrapyramidal symptoms, and reduce the risperidone dose if they appear. Correct electrolyte abnormalities and avoid adding other QT-prolonging drugs.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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