Drug interactions
Eliglustat + Sevoflurane
Severity: Major
Eliglustat and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong PR, QRS and QT intervals at higher exposures. Added QTc prolongation from sevoflurane may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Eliglustat and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and repolarization.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities before anesthesia. Monitor the ECG continuously during and after the procedure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Sevoflurane?
MediHelp rates the interaction as major. Eliglustat and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat can prolong PR, QRS and QT intervals at higher exposures. Added QTc prolongation from sevoflurane may increase the risk of ventricular arrhythmia.
How serious is the interaction between Eliglustat and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities before anesthesia. Monitor the ECG continuously during and after the procedure.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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