Drug interactions
Eliglustat + Temsirolimus
Severity: Minor
Eliglustat and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and could increase temsirolimus exposure. The effect is likely small given that temsirolimus is given intravenously and cleared mainly by CYP3A4.
What this interaction means in plain words
Eliglustat and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Eliglustat inhibits P-gp, potentially reducing efflux of temsirolimus.
What to do
No empirical dose change is needed; monitor for temsirolimus toxicity and reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Temsirolimus?
MediHelp rates the interaction as minor. Eliglustat and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and could increase temsirolimus exposure. The effect is likely small given that temsirolimus is given intravenously and cleared mainly by CYP3A4.
How serious is the interaction between Eliglustat and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for temsirolimus toxicity and reduce the dose if adverse effects emerge.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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