Drug interactions
Eliglustat + Trazodone
Severity: Moderate
Eliglustat and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone may inhibit CYP2D6 weakly and prolong QT, while eliglustat itself can prolong cardiac intervals. Higher eliglustat exposure may increase arrhythmia risk, especially in patients with cardiac disease.
What this interaction means in plain words
Eliglustat and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Trazodone belongs to Central Nervous System.
Why it happens
Possible weak CYP2D6 inhibition raising eliglustat levels, plus additive QT effects.
What to do
Monitor ECG when combining, particularly in patients with heart disease or other QT risks. Consider an alternative antidepressant in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Trazodone?
MediHelp rates the interaction as moderate. Eliglustat and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone may inhibit CYP2D6 weakly and prolong QT, while eliglustat itself can prolong cardiac intervals. Higher eliglustat exposure may increase arrhythmia risk, especially in patients with cardiac disease.
How serious is the interaction between Eliglustat and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG when combining, particularly in patients with heart disease or other QT risks. Consider an alternative antidepressant in high-risk patients.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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