Drug interactions
Eliglustat + Vortioxetine
Severity: Moderate
Eliglustat and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is a CYP2D6 inhibitor, and vortioxetine is primarily metabolized by CYP2D6, so exposure may rise. Higher levels can increase nausea and other dose-related adverse effects.
What this interaction means in plain words
Eliglustat and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Vortioxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated vortioxetine metabolism by eliglustat.
What to do
Monitor for nausea and other adverse effects and consider reducing the vortioxetine dose. Titrate to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Vortioxetine?
MediHelp rates the interaction as moderate. Eliglustat and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat is a CYP2D6 inhibitor, and vortioxetine is primarily metabolized by CYP2D6, so exposure may rise. Higher levels can increase nausea and other dose-related adverse effects.
How serious is the interaction between Eliglustat and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea and other adverse effects and consider reducing the vortioxetine dose. Titrate to clinical response.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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