Drug interactions
Eliglustat + Zileuton
Severity: Moderate
Eliglustat and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is cleared by CYP2D6 and CYP3A4, and zileuton may raise its levels through weak CYP3A4 inhibition. Higher eliglustat exposure can prolong PR, QRS and QT intervals, particularly in CYP2D6 poor metabolizers.
What this interaction means in plain words
Eliglustat and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibition of CYP3A4-mediated eliglustat metabolism.
What to do
Check the patient's CYP2D6 phenotype and review other interacting drugs. Monitor ECG and symptoms of arrhythmia, and avoid the combination in poor or intermediate metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Zileuton?
MediHelp rates the interaction as moderate. Eliglustat and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat is cleared by CYP2D6 and CYP3A4, and zileuton may raise its levels through weak CYP3A4 inhibition. Higher eliglustat exposure can prolong PR, QRS and QT intervals, particularly in CYP2D6 poor metabolizers.
How serious is the interaction between Eliglustat and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the patient's CYP2D6 phenotype and review other interacting drugs. Monitor ECG and symptoms of arrhythmia, and avoid the combination in poor or intermediate metabolizers.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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