Drug interactions
Eltrombopag + Leflunomide
Severity: Minor
Eltrombopag and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide may inhibit CYP2C9, which is involved in eltrombopag oxidation. Eltrombopag exposure could increase modestly, raising the risk of hepatotoxicity.
What this interaction means in plain words
Eltrombopag and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Leflunomide belongs to Musculoskeletal.
Why it happens
Teriflunomide inhibits CYP2C9, reducing eltrombopag metabolism.
What to do
Monitor liver enzymes and platelet counts. Adjust the eltrombopag dose according to platelet response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Leflunomide?
MediHelp rates the interaction as minor. Eltrombopag and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide may inhibit CYP2C9, which is involved in eltrombopag oxidation. Eltrombopag exposure could increase modestly, raising the risk of hepatotoxicity.
How serious is the interaction between Eltrombopag and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and platelet counts. Adjust the eltrombopag dose according to platelet response.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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