Drug interactions
Eltrombopag + Talazoparib
Severity: Moderate
Eltrombopag and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits BCRP, which may increase exposure to talazoparib, a BCRP substrate. This may worsen myelosuppression, particularly anemia and thrombocytopenia.
What this interaction means in plain words
Eltrombopag and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Talazoparib belongs to Oncology.
Why it happens
BCRP inhibition by eltrombopag reduces talazoparib efflux and may raise systemic exposure.
What to do
Monitor complete blood counts closely if the combination is used. Reduce or interrupt the talazoparib dose for significant hematologic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Eltrombopag with Talazoparib?
MediHelp rates the interaction as moderate. Eltrombopag and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits BCRP, which may increase exposure to talazoparib, a BCRP substrate. This may worsen myelosuppression, particularly anemia and thrombocytopenia.
How serious is the interaction between Eltrombopag and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely if the combination is used. Reduce or interrupt the talazoparib dose for significant hematologic toxicity.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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