Drug interactions
Eluxadoline + Ergotamine
Severity: Moderate
Eluxadoline and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline may modestly inhibit CYP3A4, which could raise ergotamine concentrations. Because ergotamine has a narrow safety margin and can cause serious vasospastic ischemia, even small increases in exposure matter.
What this interaction means in plain words
Eluxadoline and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Ergotamine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by eluxadoline may decrease ergotamine metabolism.
What to do
Monitor for early signs of ergotism, including limb coldness, paresthesia and nausea. Consider an alternative migraine therapy if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Ergotamine?
MediHelp rates the interaction as moderate. Eluxadoline and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline may modestly inhibit CYP3A4, which could raise ergotamine concentrations. Because ergotamine has a narrow safety margin and can cause serious vasospastic ischemia, even small increases in exposure matter.
How serious is the interaction between Eluxadoline and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for early signs of ergotism, including limb coldness, paresthesia and nausea. Consider an alternative migraine therapy if symptoms appear.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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