Drug interactions
Eluxadoline + Everolimus
Severity: Minor
Eluxadoline and Everolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline may modestly raise exposure of CYP3A substrates, which might increase everolimus levels. The effect is probably small, but everolimus has a narrow therapeutic range.
What this interaction means in plain words
Eluxadoline and Everolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Everolimus belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4 reducing everolimus metabolism.
What to do
Monitor everolimus trough concentrations when eluxadoline is started and adjust the dose if levels rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Everolimus?
MediHelp rates the interaction as minor. Eluxadoline and Everolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline may modestly raise exposure of CYP3A substrates, which might increase everolimus levels. The effect is probably small, but everolimus has a narrow therapeutic range.
How serious is the interaction between Eluxadoline and Everolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations when eluxadoline is started and adjust the dose if levels rise.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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