Drug interactions
Eluxadoline + Fexofenadine
Severity: Minor
Eluxadoline and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits OATP1B1 and may increase exposure to fexofenadine, which relies on organic anion transporters. The clinical consequence is likely small given fexofenadine's wide safety margin.
What this interaction means in plain words
Eluxadoline and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Fexofenadine belongs to Respiratory.
Why it happens
Inhibition of OATP-mediated transport by eluxadoline raises fexofenadine exposure.
What to do
No dose adjustment is usually needed; monitor for increased fexofenadine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Fexofenadine?
MediHelp rates the interaction as minor. Eluxadoline and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline inhibits OATP1B1 and may increase exposure to fexofenadine, which relies on organic anion transporters. The clinical consequence is likely small given fexofenadine's wide safety margin.
How serious is the interaction between Eluxadoline and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for increased fexofenadine adverse effects.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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