Drug interactions
Eluxadoline + Gemfibrozil
Severity: Moderate
Eluxadoline and Gemfibrozil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil inhibits OATP1B1, a hepatic uptake transporter for eluxadoline, and raises eluxadoline exposure. This may increase adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Eluxadoline and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Gemfibrozil belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of eluxadoline increases plasma concentrations.
What to do
Reduce eluxadoline to the lower labeled dose of 75 mg twice daily if an OATP1B1 inhibitor is needed. Monitor for constipation and abdominal pain, and stop if pancreatitis is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Gemfibrozil?
MediHelp rates the interaction as moderate. Eluxadoline and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil inhibits OATP1B1, a hepatic uptake transporter for eluxadoline, and raises eluxadoline exposure. This may increase adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Eluxadoline and Gemfibrozil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to the lower labeled dose of 75 mg twice daily if an OATP1B1 inhibitor is needed. Monitor for constipation and abdominal pain, and stop if pancreatitis is suspected.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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