Drug interactions
Eluxadoline + Oxycodone
Severity: Moderate
Eluxadoline and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline acts on opioid receptors in the gut and can cause constipation and sphincter of Oddi spasm. Combined with an opioid, there is a higher risk of serious constipation-related complications.
What this interaction means in plain words
Eluxadoline and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive reduction of gastrointestinal motility through opioid receptor effects.
What to do
Avoid long-term coadministration and stop eluxadoline if severe constipation develops. Monitor bowel function and abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Oxycodone?
MediHelp rates the interaction as moderate. Eluxadoline and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline acts on opioid receptors in the gut and can cause constipation and sphincter of Oddi spasm. Combined with an opioid, there is a higher risk of serious constipation-related complications.
How serious is the interaction between Eluxadoline and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term coadministration and stop eluxadoline if severe constipation develops. Monitor bowel function and abdominal pain.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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