Drug interactions
Eluxadoline + Tramadol
Severity: Moderate
Eluxadoline and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a mu-opioid agonist for IBS with diarrhea, and opioids like tramadol increase the risk of constipation and serious complications such as ileus or pancreatitis-related events. The combination also adds CNS effects.
What this interaction means in plain words
Eluxadoline and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Tramadol belongs to Musculoskeletal.
Why it happens
Additive opioid-receptor mediated reduction of gastrointestinal motility.
What to do
Avoid concurrent chronic use where possible. If used, monitor for constipation and abdominal pain and stop eluxadoline if severe constipation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Tramadol?
MediHelp rates the interaction as moderate. Eluxadoline and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is a mu-opioid agonist for IBS with diarrhea, and opioids like tramadol increase the risk of constipation and serious complications such as ileus or pancreatitis-related events. The combination also adds CNS effects.
How serious is the interaction between Eluxadoline and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent chronic use where possible. If used, monitor for constipation and abdominal pain and stop eluxadoline if severe constipation develops.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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