Drug interactions
Eluxadoline + Zileuton
Severity: Minor
Eluxadoline and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton is a CYP1A2 inhibitor, and eluxadoline is primarily cleared by other routes but may have some CYP1A2 involvement. Exposure to eluxadoline could rise, though the clinical effect is not well characterized.
What this interaction means in plain words
Eluxadoline and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Zileuton belongs to Respiratory.
Why it happens
Possible inhibition of CYP1A2-mediated eluxadoline metabolism by zileuton.
What to do
No dose change is usually needed. Monitor for eluxadoline adverse effects such as constipation, nausea and abdominal pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eluxadoline and Zileuton, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Zileuton?
MediHelp rates the interaction as minor. Eluxadoline and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zileuton is a CYP1A2 inhibitor, and eluxadoline is primarily cleared by other routes but may have some CYP1A2 involvement. Exposure to eluxadoline could rise, though the clinical effect is not well characterized.
How serious is the interaction between Eluxadoline and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for eluxadoline adverse effects such as constipation, nausea and abdominal pain.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
