Drug interactions
Empagliflozin + Glibenclamide
Severity: Moderate
Empagliflozin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin on its own carries a low hypoglycemia risk, but together with glyburide the risk rises noticeably. Episodes may be prolonged because of glyburide's long action.
What this interaction means in plain words
Empagliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering through SGLT2 inhibition and insulin secretagogue activity.
What to do
Consider reducing the glyburide dose when empagliflozin is initiated. Monitor glucose and counsel on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Glibenclamide?
MediHelp rates the interaction as moderate. Empagliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin on its own carries a low hypoglycemia risk, but together with glyburide the risk rises noticeably. Episodes may be prolonged because of glyburide's long action.
How serious is the interaction between Empagliflozin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when empagliflozin is initiated. Monitor glucose and counsel on hypoglycemia symptoms.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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