Drug interactions
Empagliflozin + Indapamide
Severity: Moderate
Empagliflozin and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin causes osmotic diuresis and mild natriuresis, which adds to the effect of indapamide. This can lead to volume depletion, hypotension and acute kidney injury, particularly in older or frail patients.
What this interaction means in plain words
Empagliflozin and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects leading to intravascular volume depletion.
What to do
Assess volume status and blood pressure before and after starting empagliflozin, and consider reducing the indapamide dose in at-risk patients. Monitor renal function and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Indapamide?
MediHelp rates the interaction as moderate. Empagliflozin and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin causes osmotic diuresis and mild natriuresis, which adds to the effect of indapamide. This can lead to volume depletion, hypotension and acute kidney injury, particularly in older or frail patients.
How serious is the interaction between Empagliflozin and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and blood pressure before and after starting empagliflozin, and consider reducing the indapamide dose in at-risk patients. Monitor renal function and electrolytes.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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