Drug interactions
Empagliflozin + Insulin lispro protamine / insulin lispro
Severity: Moderate
Empagliflozin and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding empagliflozin to insulin lowers glucose further and raises the risk of hypoglycemia. Insulin requirements often fall, and ketoacidosis risk rises if insulin is cut too much.
What this interaction means in plain words
Empagliflozin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering through insulin action and insulin-independent urinary glucose excretion.
What to do
Monitor glucose closely and consider a modest insulin dose reduction when starting empagliflozin. Avoid large insulin reductions and watch for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Empagliflozin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding empagliflozin to insulin lowers glucose further and raises the risk of hypoglycemia. Insulin requirements often fall, and ketoacidosis risk rises if insulin is cut too much.
How serious is the interaction between Empagliflozin and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and consider a modest insulin dose reduction when starting empagliflozin. Avoid large insulin reductions and watch for ketoacidosis symptoms.
What other medicines interact with Empagliflozin?
MediHelp also lists interactions of Empagliflozin with, for example, Amiloride, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Empagliflozin page.
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