Drug interactions
Empagliflozin + Lonapegsomatropin
Severity: Moderate
Empagliflozin and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity and can raise blood glucose, which may offset the effect of empagliflozin. Glycemic control in diabetic patients may worsen.
What this interaction means in plain words
Empagliflozin and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and counteracts glucose-lowering therapy.
What to do
Monitor blood glucose and HbA1c when starting or adjusting lonapegsomatropin. Increase antihyperglycemic doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Empagliflozin with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Empagliflozin and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and can raise blood glucose, which may offset the effect of empagliflozin. Glycemic control in diabetic patients may worsen.
How serious is the interaction between Empagliflozin and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or adjusting lonapegsomatropin. Increase antihyperglycemic doses if needed.
What other medicines interact with Empagliflozin?
MediHelp also lists interactions of Empagliflozin with, for example, Amiloride, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Empagliflozin page.
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