Drug interactions
Empagliflozin + Methyclothiazide
Severity: Moderate
Empagliflozin and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin adds osmotic diuresis to the natriuretic effect of a thiazide, which can lead to volume depletion. Hypotension, dizziness and reduced kidney function may follow, especially in older patients.
What this interaction means in plain words
Empagliflozin and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive diuretic and natriuretic effects at different nephron sites.
What to do
Assess volume status and renal function before and after starting empagliflozin, and monitor blood pressure and electrolytes. Reduce the thiazide dose if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Methyclothiazide?
MediHelp rates the interaction as moderate. Empagliflozin and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin adds osmotic diuresis to the natriuretic effect of a thiazide, which can lead to volume depletion. Hypotension, dizziness and reduced kidney function may follow, especially in older patients.
How serious is the interaction between Empagliflozin and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting empagliflozin, and monitor blood pressure and electrolytes. Reduce the thiazide dose if volume depletion develops.
What other medicines interact with Empagliflozin?
MediHelp also lists interactions of Empagliflozin with, for example, Amiloride, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Empagliflozin page.
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