Drug interactions
Enalapril-hydrochlorothiazide + Maraviroc
Severity: Moderate
Enalapril-hydrochlorothiazide and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc can cause postural hypotension, particularly in patients with renal impairment or on other blood pressure lowering drugs. Combined with an ACE inhibitor and thiazide, dizziness and fainting may be more likely.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Maraviroc belongs to Anti Virals.
Why it happens
Additive blood pressure lowering effects (pharmacodynamic).
What to do
Check orthostatic blood pressure when starting maraviroc and counsel patients to rise slowly. Reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Maraviroc?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc can cause postural hypotension, particularly in patients with renal impairment or on other blood pressure lowering drugs. Combined with an ACE inhibitor and thiazide, dizziness and fainting may be more likely.
How serious is the interaction between Enalapril-hydrochlorothiazide and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check orthostatic blood pressure when starting maraviroc and counsel patients to rise slowly. Reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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