Drug interactions
Enalapril-hydrochlorothiazide + Vildagliptin
Severity: Minor
Enalapril-hydrochlorothiazide and Vildagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can modestly raise blood glucose and may reduce the glycemic benefit of vildagliptin. The effect is usually small and manageable.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Vildagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Vildagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazide-related reduction in insulin secretion and sensitivity.
What to do
Monitor glucose control when starting or adjusting the thiazide and intensify diabetes therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Vildagliptin
- Ciprofloxacin + Vildagliptin Moderate
- Deflazacort + Vildagliptin Moderate
- Dexamethasone + Vildagliptin Moderate
- Gemifloxacin + Vildagliptin Moderate
- Glimepiride + Vildagliptin Moderate
- Hydrochlorothiazide-lisinopril + Vildagliptin Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Vildagliptin?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Vildagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can modestly raise blood glucose and may reduce the glycemic benefit of vildagliptin. The effect is usually small and manageable.
How serious is the interaction between Enalapril-hydrochlorothiazide and Vildagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control when starting or adjusting the thiazide and intensify diabetes therapy if needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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