Drug interactions
Entacapone + Finerenone
Severity: Minor
Entacapone and Finerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is metabolized mainly by CYP3A4, and inhibitors can increase exposure and the risk of hyperkalemia. Entacapone is not an established inhibitor of CYP3A4 or CYP2E1, so a clinically relevant effect is unlikely.
What this interaction means in plain words
Entacapone and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Finerenone belongs to Cardiovascular.
Why it happens
Theoretical CYP3A4 inhibition by entacapone; not clinically established.
What to do
Monitor serum potassium and renal function according to finerenone labeling. No preemptive dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Entacapone with Finerenone?
MediHelp rates the interaction as minor. Entacapone and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Finerenone is metabolized mainly by CYP3A4, and inhibitors can increase exposure and the risk of hyperkalemia. Entacapone is not an established inhibitor of CYP3A4 or CYP2E1, so a clinically relevant effect is unlikely.
How serious is the interaction between Entacapone and Finerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function according to finerenone labeling. No preemptive dose change is needed.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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