Drug interactions
Entacapone + Gepirone
Severity: Minor
Entacapone and Gepirone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is metabolized by CYP3A4, and moderate or strong inhibitors raise its exposure, with a risk of dizziness, sedation and QT prolongation. Entacapone is not a recognized clinically meaningful CYP3A4 inhibitor, so the interaction is mostly theoretical.
What this interaction means in plain words
Entacapone and Gepirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Theoretical CYP3A4 inhibition reducing gepirone clearance.
What to do
Monitor for dizziness, sedation and adverse effects after starting the combination. Reduce the gepirone dose only if clinically significant exposure increase is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Entacapone with Gepirone?
MediHelp rates the interaction as minor. Entacapone and Gepirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gepirone is metabolized by CYP3A4, and moderate or strong inhibitors raise its exposure, with a risk of dizziness, sedation and QT prolongation. Entacapone is not a recognized clinically meaningful CYP3A4 inhibitor, so the interaction is mostly theoretical.
How serious is the interaction between Entacapone and Gepirone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, sedation and adverse effects after starting the combination. Reduce the gepirone dose only if clinically significant exposure increase is suspected.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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